The next generation of industrial biotechnology completes the pilot production of new materials at low prices

HC Plastics News: Recently, the “Next Generation Industrial Biotechnology” press conference and the signing ceremony of the Tsinghua University Life Science Center (Synthesis and Systems Biology Center) and the Yinzhou District Government were held at the Jining Shengdu International Conference Center.

The “Next Generation Industrial Biotechnology” platform was initiated by Chen Guoqiang, Distinguished Professor of “Changjiang Scholars” at the College of Life Sciences of Tsinghua University. In order to accelerate the transformation of production, research and research of this technology, Parkson Biotech and Tsinghua University jointly established Shandong Parkson Lansu Biotechnology Co., Ltd. The research and development of biological grade biodegradable new material (PHA) project has completed the pilot test of industrialization, and realized the low-cost PHA mass production capacity without sterilization and continuous continuous fermentation, which has played a historical role in promoting the transformation and upgrading of China's bio-manufacturing industry.

The project uses the world's largest plastic bioreactor, with high technology content, ecological and environmental protection, and is far ahead of the international peers. In order to fully integrate the research resources of Tsinghua University and promote the upgrading of the industry in Yinzhou District, the Yinzhou District Government and the Tsinghua University Life Science Academy (Synthesis and Systems Biology Center) signed a strategic cooperation agreement to provide intellectual support for the transformation of the new and old kinetic energy of the industry. .

Also attending the event were university experts from Tsinghua University, Shanghai Jiaotong University, East China University of Science and Technology, Jiangnan University, Shandong University, and the director of the Zhangzhou District Committee, the director of the district committee, Qu Yaowu, the deputy head of the district, Fu Fumei, and the deputy secretary of the Zhangzhou Industrial Park. Director Gong Biao et al.

"Next-generation industrial biotechnology" is an industrial bio-based manufacturing based on extreme microbial synthetic biology, which can overcome the shortcomings of existing bio-manufacturing, promote the comprehensive upgrading of bio-manufacturing in China, and solve the ecological, resource and sustainable development crisis. This project has successfully carried out a pilot test of 5 tons in Jinzhou, Shandong Province, and will build a production facility of 1,000 tons next year. In the second half of next year, the existing idle equipment will be used to realize the production of 50,000 tons of materials, and the layout will continue in the Northeast in the following year.

The project has three highlights: First, to achieve high-efficiency production without sterilized open continuous fermentation, reduce sterilization energy consumption and complex operations, and greatly reduce labor costs; second, the cultivation of halophilic microorganisms requires high concentration of salt substrate culture Base, high-salt wastewater can be used to replace freshwater resources, which greatly saves water resources. Third, the bioreactor uses materials such as plastic or ceramics, and does not require high-temperature and high-pressure stainless steel materials, which greatly reduces production costs.

At the beginning of the research and development, the polyhydroxyalkanoate (PHA) production strain was verified by the small-scale production of the 7-liter fermenter. Subsequently, the industrialization technical team successfully completed the pilot test at the Shandong Parkson R&D Center. The pilot-scale amplification production combined with the open non-sterilization. The fermentation process and the downstream post-extraction process have successfully achieved continuous batch production of PHA powder, and the total cost is reduced by 50%.

It is understood that PHA, as a high-performance bio-based degradable material, can be processed into pellets for downstream end products processing according to different application requirements. At present, PHA pellets have been used in degradable agricultural film, disposable wood powder blending and pure PHA tableware, color 3D printing silk, electrospun fiber, shopping bags and other end products.

Editor in charge: Wang Ning 12

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